We are reviewing some Anti-Aging Supplements with special application to preventing or even reversing cognitive decline. Neutral tissue is distinct from other types of tissue, but the same supplements which maintain a healthy brain may also support heart health becauase the heart contains 40,000 neurons and the vagal neural system branches into the glandular and digestive process, so protecting the brain may also benefit health overall.
If you are or an acquaintance is facing memory impairment or disorientation, it might be worth while to look up such studies. Another one that comes to mind is the necessity for good sleep, with at least two hours nightly of REM sleep. This can be helped by habits as simple as what I call a liquid curfew- not drinking anything 5 or 6 hours prior to bedtime. Liquid in is liquid out. If you do not want to have to make nocturnal toilet visits for urination, you will find that ceasing fluid intake several hours prior to bedtime is helpful. You might ask about taking supplements or medicines best taken at bedtime. I personally take a GABA pill and have a shilaji gummie about an hour prior to planed sleep. I “wash it down” wiht a stick of celery, a couple of slices of cucumber, or a slice of apple. It works just as well as a glass of water without waking me up later. A final suggestion for sleep is to discontinue viewing computer, tablet, or cellphone screens at least an hour prior to bedtime. All of this helps one to relax, release, allow the brain’s chemical cleansing and renewal associated with good rest.
The supplements below are important to consider for protecting cognitive / neural function, but behavioral habits may play a role also. I recall reading a Lancet study about successful cognitive ageing. In it, the observation was made that rather than just walking for exercise, briskly walking is useful. Swinging one’s arms front and back (being careful to avoid hitting any bicyclists or children on the walkway) really helps with cephalic circulation and has been linked to prevention of decline. There is increasing emphasis in neurology and endocrinology on “feedback loops.” This is proveable in the orthomolecular framework, but I think there is a macro sense of feedback loops as well. Consider that thre is a correlation between how quickly an older person walks and his/her predictable lifespan. Increase your pace: extent your life. I dont have time nor space to chase down all these studies, but, if you or someone you know is facing memory impairment or disorientation, it is well worthwhile to search and read such articles on self-help in preserving cognitive health.
Here, then, we review some supplements documented to protect brain health:
Pychogenol for mental focus, anxiety reduction and general mental preservation of function:
Pycnogenol Mental Health
Pycnogenol, a standardized extract from the bark of the French maritime pine tree (Pinus pinaster), has been studied for its potential benefits on mental health across various populations. Research indicates that Pycnogenol may improve cognitive function, attention, mental performance, and mood by reducing oxidative stress and supporting brain health.
In a study involving healthy professionals aged 35-55, supplementation with Pycnogenol (150 mg/day) for 12 weeks led to significant improvements in cognitive function, sustained attention, memory, and mood, alongside a 30.4% median reduction in plasma-free radicals (oxidative stress) compared to controls. Participants also reported decreased anxiety and increased contentedness, which researchers linked to the reduction in oxidative stress.
For younger individuals, Pycnogenol has shown promise in enhancing mental performance in students. An 8-week study found that students taking Pycnogenol experienced significant improvements in sustained attention, memory, executive functions, and mood. Another study reported a 17% decrease in test anxiety and improved mental performance among college students.
Pycnogenol has also been investigated for its effects on children with Attention Deficit Hyperactivity Disorder (ADHD). A clinical trial on children aged 9-10 found that Pycnogenol supplementation (1 mg/kg bodyweight) significantly lowered stress hormones like adrenaline by 26.2% and decreased dopamine levels by 10.8%, leading to reduced hyperactivity and normalized catecholamine concentrations. The study concluded that Pycnogenol helps reduce oxidative stress associated with ADHD.
Furthermore, animal studies support its neuroprotective effects. In a mouse model of depression, Pycnogenol reduced depression-like behaviors, likely through its antioxidant activity. In a rat model of traumatic brain injury, Pycnogenol treatment reduced markers of oxidative stress and inflammation in the brain. The extract is believed to cross the blood-brain barrier and may influence brain function by modifying membrane fluidity and protecting neurons from oxidative damage.
Overall, the body of research suggests that Pycnogenol may serve as a natural supplement to support mental health, particularly in improving cognitive performance, reducing anxiety, and managing symptoms associated with ADHD and stress-related conditions.
As a general rule 100mg twice daily for 200lb weight.
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Bacopa Monnieri for neurological protection and prevention of plaques:
Bacopa Monnieri Alzheimer
Bacopa monnieri, a traditional medicinal herb, is being investigated for its potential in treating Alzheimer’s disease (AD) due to its neuroprotective properties and ability to target key pathological features of the disease. Research indicates that its phytochemicals, particularly Bacopaside I, exhibit superior binding affinity and a unique interaction profile with β-site amyloid precursor protein cleaving enzyme 1 (BACE1), a critical enzyme in the production of amyloid-beta (Aβ) peptides, which form the plaques characteristic of AD. This suggests Bacopa monnieri phytochemicals could serve as promising natural alternatives to synthetic BACE1 inhibitors, potentially overcoming the limitations seen in clinical trials of drugs like Atabecestat, Lanabecestat, and Verubecestat, which failed due to toxicity or lack of cognitive benefit despite reducing Aβ levels.
Preclinical studies in animal models support this potential. In rats with Aβ42-induced AD-like pathology, oral administration of Bacopa monnieri extract significantly ameliorated cognitive impairment and compromised explorative behavior. The treatment reduced oxidative stress, proinflammatory cytokines, and cholinesterase activity, while also restoring the balance of Bax/Bcl-2 proteins, increasing neurotrophic factors, and preventing neurodegeneration. Notably, the treatment eliminated amyloid plaques in the hippocampus and normalized the abnormal increase in both phosphorylated and total tau protein levels, which are associated with neurofibrillary tangles. The mechanism involves the herb’s interaction with glycogen synthase kinase (GSK-3β), leading to the restoration of the Wnt/β-catenin signaling pathway, a crucial pathway for memory, particularly in healthy adults and older individuals. These benefits were observed in diverse populations, including healthy children, young adults, and elderly subjects. Furthermore, Bacopa monnieri has been shown to reduce Aβ deposition and protect cholinergic neurons, with its effects on cholinesterase activity comparable to standard AD medications like donepezil and rivastigmine. The herb is generally well-tolerated, with mild gastrointestinal side effects reported, and no serious complications or genotoxicity observed in experimental studies.
Bacopa Monnieri 200mg Capsuleshttps://carlylenutritionals.com/products/bacopa-monnieri-1000-mg-capsules-180-count?_pos=1&_psq=Bacopa&_ss=e&_v=1.0
(PEA), the neuroprotector
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N-acetylanolamine class of phospholipids was first isolated from soy lecithin, egg yolk, and peanut flour. It is currently used for the treatment of different types of neuropathic pain, such as fibromyalgia, osteoarthritis, carpal tunnel syndrome, and many other conditions. The properties of PEA, especially of its micronized or ultra-micronized forms maximizing bioavailability and efficacy, have sparked a series of innovative research to evaluate its possible application as therapeutic agent for neurodegenerative diseases. Neurodegenerative diseases are widespread throughout the world, and although they are numerous and different, they share common patterns of conditions that result from progressive damage to the brain areas involved in mobility, muscle coordination and strength, mood, and cognition. The present review is aimed at illustrating in vitro and in vivo research, as well as human studies, using PEA treatment, alone or in combination with other compounds, in the presence of neurodegeneration. Namely, attention has been paid to the effects of PEA in counteracting neuroinflammatory conditions and in slowing down the progression of diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. Literature research demonstrated the efficacy of PEA in addressing the damage typical of major neurodegenerative diseases.
Keywords: PEA, ALIAmides, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Frontotemporal dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, neuroinflammation
BulkSupplements.com Palmitoylethanolamide Capsules – Pea Supplement, Palmitoylethanolamide 600mg for Immmune Support – Gluten Free, 1 Capsule per Serving, 180 Capsules (Pack of 1) https://a.co/d/9dHJfLL
Jacobo Grinberg’s manipulation of consciousness so that the conscious field will support rejuvenation: https://youtu.be/Dcqx_6u86s0?si=P8b-oRYWqLcKaChs
Nitric Oxide’s role in preventing Alzheimer’s Disease and in providing more cellular energy with less oxygen and at around minute 30, NO helps mobilization of pleuripotent stem cells, allowing for repair of telomeres. It increases telomerase, allow restoration of these strands, which otherwise diminish after successive divisions. From about minute 1:07, he starts discussing how Alzheimer’s is a vascular disease and some key ways that NO prevents or even to some extent may reverse Alzheimer’s:
improves blood flow to brain
reduces neural inflammation
prevents the oxidative stress which results in misfolded Tau and amyloid-beta plaque proteins
protects against insulin resistance, protecting insulin signaling as impaired brain glucose metabolism is a known factor in AD
Preventing or even reversing amyloid plaque and tau protein deposition in Alzheimer’s Disease through lithium orotate:
“Research published in Nature in August 2025 indicates that lithium deficiency in the brain may be an early event in the development of Alzheimer’s disease (AD), with lithium orotate emerging as a promising candidate for potential prevention and treatment. Studies found that lithium levels were significantly reduced in the prefrontal cortex of individuals with mild cognitive impairment (MCI) and AD, and that amyloid plaques sequester lithium, reducing its bioavailability in brain regions critical for memory and decision-making. In mouse models, depleting dietary lithium led to increased amyloid-β deposition, tau accumulation, neuroinflammation, synapse and myelin loss, and accelerated cognitive decline.
Among 16 lithium salts tested, lithium orotate (LiO) demonstrated markedly lower binding affinity for amyloid plaques compared to lithium carbonate, allowing it to bypass sequestration and restore lithium levels in non-plaque brain regions. Low-dose lithium orotate treatment reversed amyloid and tau pathology, synapse and myelin loss, microgliosis, and memory impairment in both AD mouse models and normal aging mice. In aging mice with advanced disease, lithium orotate almost completely reversed memory loss and reduced amyloid plaque burden by 70%. Notably, long-term treatment with lithium orotate did not show signs of kidney or thyroid toxicity, a concern with higher-dose lithium carbonate used for bipolar disorder.
The study suggests that lithium orotate, by maintaining physiological lithium levels, could prevent or reverse key pathological features of AD and brain aging. The researchers emphasize that while these findings are promising, clinical trials are needed to determine safe and effective dosing in humans. A clinical trial for lithium orotate is planned to begin in the near future.”
The above references to specific products are offered not as an endorsement of a particular brand nor a suggested dosage, but only as examples of the kinds of products in use in each supplement and the common dosage which consumers are using.
;Nutritional support supplements discussed above are offered for evaluation only. This a pastoral healing service based upon psychic and energetic approaches to healing. Use of herbal or homeopathic remedies is based upon the literature of each discipline and on anecdotal experiences of clients or practitioners who have used these over many millennia in the ancient Scandinavian tradition of Tietaja. In some modern Tietajar training, we shamanic students learn global herbalism and so suggestions may use herbs employed in diverse indigenous healing traditions including our own in Northern Europe. Do research the uses and applications of components yourself and discuss it with a licensed healthcare professional prior to using.